STAT3 Expression and Activity are Up‐Regulated in Diffuse ... | 寵物協尋網
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由AAssumpção著作·2018·被引用11次—2,3Hence,CHOP‐basedchemotherapyremainsthestandardofcarefordogswithDLBCL,andthereisasubstantialneedforidentifyingnewtherapeutictargets ...
![STAT3 Expression and Activity are Up‐Regulated in Diffuse ...](https://i.imgur.com/voy7JL0.jpg)
The Janus Kinase (JAK) and Signal Transducer and Activator of Transcription (STAT) pathways play important roles in the pathogenesis of diffuse large B cell lymphoma (DLBCL) in humans, and up‐regulated STAT3 expression and activity are associated with worse clinical outcome in humans. No studies have evaluated the JAK‐STAT signaling pathway in DLBCL of dogs.
HypothesisSTAT3 pathway is deregulated in DLBCL in dogs. We aim to assess the expression, activation, and cellular localization of STAT3 and mitogen‐activated protein kinase ERK1/2 in DLBCL of dogs.
AnimalsForty‐three client‐owned dogs diagnosed with DLBCL by histopathology
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