STAT3 Expression and Activity are Up | 寵物協尋網
由AAssumpção著作·2018·被引用11次—3DepartmentofPathobiologicalSciences,SchoolofVeterinaryMedicine,Universityof...PMID:29119628;PMCID:PMC5787155;DOI:10.1111/jvim.14860 ...
Background: The Janus Kinase (JAK) and Signal Transducer and Activator of Transcription (STAT) pathways play important roles in the pathogenesis of diffuse large B cell lymphoma (DLBCL) in humans, and up-regulated STAT3 expression and activity are associated with worse clinical outcome in humans. No studies have evaluated the JAK-STAT signaling pathway in DLBCL of dogs.
Hypothesis: STAT3 pathway is deregulated in DLBCL in dogs. We aim to assess the expression, activation, and cellular localization of STAT3 and mitogen-activated protein kinase ERK1/2 in DLBCL of dogs.
Animals: Forty-three client-owned dogs diagnosed with DLBCL by histopathology METHODS: Retrospective analysis of DLBCL in dogs, including patient characteristics and treatment, immunohistochemistry, and protein expressions by Western blot.
Results: A higher percentage of STAT3 and p-STAT3 immunolabelled cel...
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