Proteomic Profiling of Diffuse Large B | 寵物協尋網
![Proteomic Profiling of Diffuse Large B](https://i.imgur.com/voy7JL0.jpg)
由AKwiecińska著作·2018·被引用6次—CollegeofMedicine,QatarUniversity,Doha,Qatar.PMID:29617697;DOI:10.1159/000486285.Abstract.
![Proteomic Profiling of Diffuse Large B](https://i.imgur.com/voy7JL0.jpg)
Objective: The aim of this study was to identify differences in proteome profiles of diffuse large B-cell lymphoma (DLBCL) of nongerminal center (non-GC) versus GC type in the search for new markers and drug targets.
Methods: Six DLBCL, with 3 repeats for each, were used for the initial study by proteomics: 3 non-GC and 3 GC DLBCL cases. For immunohistochemistry, tissue microarrays were made from 31 DLBCL samples: 16 non-GC de novo lymphomas and 15 GC cases (11 transformed from follicular lymphomas and 4 de novo GC lymphomas). Proteome profiling was performed by two-dimensional gel electrophoresis and MALDI-TOF mass spectrometry.
Results: Ninety-one proteins were found differentially expressed in non-GC compared to GC type. The Cytoscape tool was used for systemic analysis of proteomics data, revealing 19 subnetworks representing functions affected in non-GC versus GC types of DLBCL...
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