US5395624A | 寵物協尋網
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Publicationnumber:US5395624A;US5395624AUS08/083,376US8337693A...JP3162342B2(en),2001-04-25,Useofarbutinmonoesterasdepigmentingagent.
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The present application concerns a depigmenting cosmetic or dermatological composition containing, as an active ingredient, at least one di- or tri-caffeoylquinic acid. The composition according to the invention is intended to whiten skin or to treat pigmentation spots.
It will be remembered that the skin pigmentation-formation mechanism, i.e., the melanin-formation mechanism, is especially complex and entails the following main steps, indicated schematically:
Tyrosine → Dopa → Dopaquinone → Dopachrome → Melanins.tyrosinase being the basic enzyme involved in this series of reactions.
The substances most widely used at present as depigmenting agents are, most notably, hydroquinone and its derivatives, and especially its ethers, e.g., hydroquinone monomethyl ether.
While these compounds do posses a degree of efficacy, they do, unfortunately, produce side-effects,...
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