Effects of GF-015535 | 寵物協尋網
![Effects of GF-015535](https://i.imgur.com/voy7JL0.jpg)
由CAnaclet著作·2012·被引用14次—PMID:22215924·PMCID:PMC3242675·DOI:10.5665/sleep.1596 ...
![Effects of GF-015535](https://i.imgur.com/voy7JL0.jpg)
Study objectives: Novel, safe, and efficient hypnotic compounds capable of enhancing physiological sleep are still in great demand in the therapy of insomnia. This study compares the sleep-wake effects of a new α1 GABA(A) receptor subunit ligand, GF-015535-00, with those of zolpidem, the widely utilized hypnotic compound.
Methods: Nine C57Bl6/J male mice were chronically implanted with electrodes for EEG and sleep-wake monitoring. Each mouse received 3 doses of GF-015535-00 and zolpidem. Time spent in sleep-wake states and cortical EEG power spectra were analyzed.
Results: Both zolpidem and GF-015535-00 prominently enhanced slow wave sleep and paradoxical sleep in the mouse. However, as compared with zolpidem, GF-015535-00 showed several important differences: (1) a comparable sleep-enhancing effect was obtained with a 10 fold smaller dose; (2) the induced sleep was less fragmented; ...
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Effects of GF-015535-00 | 寵物協尋網
Effects of GF-015535 | 寵物協尋網
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