The effect of diazepam on hippocampal EEG in relation to ... | 寵物協尋網
由MCaudarella著作·1987·被引用26次—Affiliation.1LaboratoiredePsychophysiologie,U.A.-C.N.R.S.339,UniversitédeBordeaux1,France.PMID:3427452;DOI:10.1016/0006-8993(87)91602-7 ...
Male mice of the BALB/cByJ and C57BL/6 strains were implanted with electrodes in the CA1 area of the hippocampus to record rhythmic slow-wave activity (RSA) or theta EEG activity. The EEG spectral characteristics and the animals motor behavior were studied while the animals walked on a moving belt (2.2 cm/s) both before and after i.p. injections of diazepam (Valium, 2 mg/kg) or vehicle. EEG spectral analyses were carried out on-line by computer. Diazepam produced a dissociation of locomotion and RSA. (1) Uninjected and vehicle-injected mice showed typical RSA (7-8 Hz) while walking. (2) Under diazepam, 7-8 Hz RSA virtually disappeared and was replaced in the temporally averaged records by RSA with a sharp, narrow-band peak at 4-5 Hz. (3) This lower-frequency RSA was associated with immobility if, and only if, the immobility immediately followed walking. This was true whether the animal itself stopped walking or the ...
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The effect of diazepam on hippocampal EEG in relation to ... | 寵物協尋網
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