The beta | 寵物協尋網
![The beta](https://i.imgur.com/voy7JL0.jpg)
由SGuida著作·1984·被引用23次—Authors.SGuida,BGiglioni,PComi,SOttolenghi,CCamaschella,GSaglio.PMID:6327288;PMCID:PMC557427;DOI:10.1002/j.1460-2075.1984.tb01885.x ...
![The beta](https://i.imgur.com/voy7JL0.jpg)
Sardinian delta beta 0-thalassemia is an inherited syndrome characterized by the inactivity of the beta-globin gene and the persistent activity of the fetal gamma-globin genes, particularly the A gamma-globin gene. Previous mapping studies with restriction enzymes failed to show any abnormality in the non-alpha globin gene cluster. We have now examined the possibility that this syndrome might result from a single rather than two different defects. Restriction enzyme polymorphisms linked to the delta beta 0-thalassemic non-alpha globin fragments were defined providing the basis for cloning the delta beta 0-thalassemic beta-globin gene from the DNA of a heterozygous patient. This gene appears to carry a C----T single mutation causing the appearance of a stop codon at amino acid position 39 of the beta-globin gene. This mutation was previously reported in beta 0-thalassemic patients, in linkage with different haplotype...
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The beta | 寵物協尋網
The beta | 寵物協尋網
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