Efficacy of cultivated corneal epithelial stem cells for ocular ... | 寵物協尋網
![Efficacy of cultivated corneal epithelial stem cells for ocular ...](https://i.imgur.com/voy7JL0.jpg)
由PPrabhasawat著作·2012·被引用68次—DepartmentofOphthalmology,FacultyofMedicine,SirirajHospital,MahidolUniversity,Bangkok,Thailand.PMID:23055668;PMCID:PMC3460717;DOI:10.2147/OPTH ...
![Efficacy of cultivated corneal epithelial stem cells for ocular ...](https://i.imgur.com/voy7JL0.jpg)
Purpose: To investigate the clinical outcomes of cultivated corneal limbal epithelial transplantation (CLET) using human amniotic membrane for corneal limbal stem-cell deficiency.
Methods: Prospective, noncomparative case series. Eighteen patients (19 eyes) with severe ocular surface diseases were chosen to undergo CLET using human amniotic membrane. Twelve eyes received auto-CLET, and seven eyes received allo-CLET. Clinical outcomes of corneal surface epithelialization, conjunctivalization, inflammation, visual acuity, graft status, and complications were observed.
Results: Corneal epithelium cultivated on amniotic membrane (two to four layers) was positive for molecular markers p63, ABCG2, CK3, and CK12. The mean patient age was 44.7 ± 15.2 years. A successful clinical outcome, defined as corneal epithelialization without central conjunctivalization or severe inflammation, was obtaine...
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